12-08-2023
Премия Вольфа по медицине присуждается один раз в год фондом Вольфа в Израиле. Это одна из шести премий Вольфа, учреждённых Фондом, она вручается с 1978; остальные премии включают в себя: сельскохозяйственную, по химии, математике, физике и в области искусств. Является одной из наиболее престижных премий в области медицины.
| Год | Лауреат | Страна | Комментарий |
|---|---|---|---|
| 1978 | Снелл, Джордж | США | for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response. |
| Доссе, Жан | Франция | for discovering the HL-A system, the major histocompatibility complex in man and its primordial role in organ transplantation. | |
| Jon J. van Rood | Нидерланды | for his contribution to the understanding of the complexity of the HL-A system in man and its implications in transplantation and in disease. | |
| 1979 | Сперри, Роджер | США | за его исследования по функциональной дифференциации правого и левого полушарий головного мозга. |
| Карлссон, Арвид | Швеция | за его работы, установившие роль допамина в качестве нейротрансмиттера. | |
| Горникевич, Олег | Австрия | за открытие нового подхода в борьбе с болезнью Паркинсона с помощью леводопы. | |
| 1980 | Мильштейн, Сезар |
Аргентина / Великобритания; |
for their contributions to knowledge of the function and dysfunction of the body cells through their studies on the immunological role of the lymphocytes, the development of specific antibodies and the elucidation of mechanisms governing the control and differentiation of normal and cancer cells. |
| 1981 | Мак-Клинток, Барбара | США | for her imaginative and important contributions to our understanding of chromosome structure behaviour and function, and for her identification and description of transposable genetic (mobile) elements. |
| Коэн, Стэнли Норман | США | for his concepts underlying genetic engineering; for constructing a biologically functional hybrid plasmid, and for achieving actual expression of a foreign gene implanted in E. coli by the recombinant DNA method. | |
| 1982 | Jean-Pierre Changeux | Франция | for the isolation, purification and characterization of the acetylcholine receptor. |
| Solomon H. Snyder | США | for the development of the ways to label neurotransmitter receptors which provide tools to describe their properties. | |
| Блэк, Джеймс | Великобритания | for developing agents which block beta adrenergic and histamine receptors. | |
| 1983/4 | Не присуждалась | ||
| 1984/5 | Donald F. Steiner | США | for his discoveries concerning the bio-synthesis and processing of insulin which have had profound implications for basic biology and clinical medicine. |
| 1986 | Хаяиси, Осаму | Япония | за открытие ферментов оксигеназы и выяснение их структуры и биологического значения. |
| 1987 | Pedro Cuatrecasas |
США |
for the invention and development of affinity chromatography and its applications to biomedical sciences. |
| 1988 | Хэрс, Генри |
Бельгия |
for the biochemical elucidation of lysosomal storage diseases and the resulting contributions to biology, pathology, prenatal diagnosis and therapeutics. |
| 1989 | Гёрдон, Джон | Великобритания | for his introduction of the xenopus oocyte into molecular biology and his demonstration that the nucleus of a differentiated cell and of the egg differ in expression but not in the content of genetic material. |
| Льюис, Эдвард | США | for his demonstration and exploration of the genetic control of the development of body segments by homeotic genes. | |
| 1990 | Maclyn McCarty | США | for his part in the demonstration that the transforming factor in bacteria is due to deoxyribonucleic acid (DNA) and the concomitant discovery that the genetic material is composed of DNA. |
| 1991 | Бензер, Сеймур | США | for having generated a new field of molecular neurogenetics by his pioneering research on the dissection of the nervous system and behavior by gene mutations. |
| 1992 | Фолкман, Джуда | США | for his discoveries which originated the concept and developed the field of angiogenesis research. |
| 1993 | Не присуждалась | ||
| 1994/5 | Берридж, Майкл Ясутоми Нисидзука |
Великобритания Япония |
за их открытия, касающиеся трансмембранной передачи сигналов с участием фосфолипидов и кальция. |
| 1995/6 | Прузинер, Стенли | США | for discovering prions, a new class of pathogens that cause important neurodegenerative disease by inducing changes in protein structure. |
| 1997 | Mary Frances Lyon | Великобритания | for her hypothesis concerning the random inactivation of X-chromosomes in mammals. |
| 1998 | Села, Майкл |
Израиль |
for their major discoveries in the field of immunology. |
| 1999 | Кандел, Эрик | США | for the elucidation of the organismic, cellular and molecular mechanisms whereby short-term memory is converted to a long-term form. |
| 2000 | Не присуждалась | ||
| 2001 | Гершко, Аврам |
Израиль; |
for the discovery of the ubiquitin system of intracellular protein degradation and the crucial functions of this system in cellular regulation. |
| 2002/3 | Ralph L. Brinster | США | for the development of procedures to manipulate mouse ova and embryos, which has enabled transgenesis and its applications in mice. |
| Капекки, Марио |
Италия / США; |
for their contribution to the development of gene-targeting, enabling elucidation of gene function in mice. | |
| 2004 | Вайнберг, Роберт | США | for his discovery that cancer cells including human tumor cells, carry somatically mutated genes-oncogenes that operate to drive their malignant proliferation. |
| Тсиен, Роджер | США | for his seminal contribution to the design and biological application of novel fluorescent and photolabile molecules to analyze and perturb cell signal transduction. | |
| 2005 | Alexander Levitzki | Израиль | for pioneering signal transduction therapy and for developing tyrosine kinase inhibitors as effective agents against cancer and a range of other diseases. |
| Хантер, Энтони | Великобритания / США | for the discovery of protein kinases that phosphorylate tyrosine residues in proteins, critical for the regulation of a wide variety of cellular events, including malignant transformation. | |
| Поусон, Энтони Джеймс | Великобритания / Канада | for his discovery of protein domains essential for mediating protein-protein interactions in cellular signaling pathways, and the insights this research has provided into cancer. | |
| 2006/7 | Не присуждалась | ||
| 2008 | Howard Cedar |
Израиль |
for their fundamental contributions to our understanding of the role of DNA methylation in the control of gene expression. |
| 2009 | Не присуждалась | ||
| 2010 | Axel Ullrich | Германия | for groundbreaking cancer research that has led to development of new drugs. |
| 2011 | Яманака, Синъя |
Япония; |
for the generation of induced pluripotent stem cells (iPS cells) from skin cells (SY) and demonstration that iPS cells can be used to cure genetic disease in a mammal, thus establishing their therapeutic potential (RJ). |
| 2012 | Эванс, Рональд Марк | США | for his discovery of the gene super-family encoding nuclear receptors and elucidating the mechanism of action of this class of receptors.[2] |
| 2013 | Не присуждалась | ||
| 2014 | Nahum Sonenberg | Израиль / Канада | for his discovery of the proteins that control the protein expression mechanism and their operation. |
| Равкан, Гэри |
США; |
for the discovery of the micro-RNA molecules that play a key role in controlling gene expression in natural processes and disease development. | |
| 2015 | Капплер, Джон Philippa Marrack Jeffrey Ravetch |
США США США |
for major contributions to the understanding of the key antigen-specific molecules, the T cell receptor for antigen and antibodies and how these molecules participate in immune recognition and effector function. |
| 2016 | Lewis Cantley | США | For discovery of phosphoinositide-3 kinases and their roles in physiology and disease |
| C. Ronald Kahn | США | For pioneering studies defining insulin signaling and its alterations in disease |
| Лауреаты премии Вольфа по медицине | |
|---|---|
|
1978: Снелл • Доссе • Ван Руд | 1979: Сперри • Карлссон • Горникевич | 1980: Мильштейн • Сакс • Гованс | 1981: Мак-Клинток • Коэн | 1982: en:Jean-Pierre Changeux • Снайдер • Блэк | 1983/84: Штайнер | 1985/86: Хаяиси | 1987: Куатрекасас • Вилчек | 1988: Хэрс • Неуфелд | 1989: Гёрдон • Льюис | 1990: Маккарти | 1991: Бензер | 1992: Фолкман | 1993/94: Берридж • Нисидзука | 1995/96: Прузинер | 1997 Mary F. Lyon | 1998: Села • Ruth Arnon | 1999: Кандел 2000/01: Гершко • Варшавский | 2002/03: Ralph L. Brinster • Капекки • Смитис | 2004: Вайнберг • Тсиен | 2005: Левицкий • Хантер • Поусон | 2008: Howard Cedar • Разин | 2010: Axel Ullrich | 2011: Яманака • Rudolf Jaenisch | 2012: Эванс | 2014: Nahum Sonenberg • Равкан • Эмброс | 2015: Капплер • Philippa Marrack • Jeffrey Ravetch |
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| Математика · Искусство · Химия · Физика · Медицина · Сельское хозяйство |
Лауреаты премии Вольфа (медицина).