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P-гликопротеин

16-07-2023

P-гликопротеин (ATP-binding cassette, sub-family B (MDR/TAP), member 1)
Кристаллическая структура P-гликопротеина
Обозначения
Символы ABCB1; P-gp, CD243, GP170, ABC20
Entrez Gene 5243
HGNC 40
OMIM 171050
RefSeq NM_000927
UniProt P08183
Другие данные
Локус 7q21.12

P-гликопротеин, или ABCB1 (ATP-binding cassette sub-family B member 1; CD243) — мембранный белок, гликопротеин из семейства ABC-переносчиков. Обеспечивает перенос многих веществ, таких как липиды, стероиды, пептиды, билирубин и др., через мембрану клетки.

Библиография

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  • Brinkmann U (2002). «Functional polymorphisms of the human multidrug resistance (MDR1) gene: correlation with P glycoprotein expression and activity in vivo». Novartis Found. Symp. 243: 207–10; discussion 210–2, 231–5. 10.1002/0470846356.ch15. PMID 11990778.
  • Váradi A, Szakács G, Bakos E, Sarkadi B (2002). «P glycoprotein and the mechanism of multidrug resistance». Novartis Found. Symp. 243: 54–65; discussion 65–8, 180–5. 10.1002/0470846356.ch5. PMID 11990782.
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  • Pallis M, Turzanski J, Higashi Y, Russell N (2003). «P-glycoprotein in acute myeloid leukaemia: therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype». Leuk. Lymphoma 43 (6): 1221–8. 10.1080/10428190290026277. PMID 12152989.
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  • Fromm MF (2003). «The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans». Adv. Drug Deliv. Rev. 54 (10): 1295–310. 10.1016/S0169-409X(02)00064-9. PMID 12406646.
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  • Jamroziak K, Robak T (2004). «Pharmacogenomics of MDR1/ABCB1 gene: the influence on risk and clinical outcome of haematological malignancies». Hematology 9 (2): 91–105. 10.1080/10245330310001638974. PMID 15203864.
  • Ishikawa T, Onishi Y, Hirano H, et al. (2005). «Pharmacogenomics of drug transporters: a new approach to functional analysis of the genetic polymorphisms of ABCB1 (P-glycoprotein/MDR1)». Biol. Pharm. Bull. 27 (7): 939–48. 10.1248/bpb.27.939. PMID 15256718.
  • Lee W, Lockhart AC, Kim RB, Rothenberg ML (2005). «Cancer pharmacogenomics: powerful tools in cancer chemotherapy and drug development». Oncologist 10 (2): 104–11. 10.1634/theoncologist.10-2-104. PMID 15709212.
  • Gambrelle J, Labialle S, Dayan G, et al. (2005). «[Multidrug resistance in uveal melanoma.]». Journal français d'ophtalmologie 28 (6): 652–9. PMID 16141933.
  • Al-Shawi MK, Omote H (2006). «The Remarkable Transport Mechanism of P-glycoprotein; a Multidrug Transporter». J. Bioenerg. Biomembr. 37 (6): 489–96. 10.1007/s10863-005-9497-5. PMID 16691488.
  • Orlowski S, Martin S, Escargueil A (2006). «P-glycoprotein and 'lipid rafts': some ambiguous mutual relationships (floating on them, building them or meeting them by chance?)». Cell. Mol. Life Sci. 63 (9): 1038–59. 10.1007/s00018-005-5554-9. PMID 16721513.
  • Annese V, Valvano MR, Palmieri O, et al. (2006). «Multidrug resistance 1 gene in inflammatory bowel disease: a meta-analysis». World J. Gastroenterol. 12 (23): 3636–44. PMID 16773678.
  • Sekine I, Minna JD, Nishio K, et al. (2007). «A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with lung cancer». Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 1 (1): 31–7. PMID 17409824.
  • Kumar YS, Adukondalu D, Sathish D, Vishnu YV, Ramesh G, Latha AB, Reddy PC, Sarangapani M, Rao YM (2010). «P-Glycoprotein- and cytochrome P-450-mediated herbal drug interactions». Drug Metabol Drug Interact 25 (1-4): 3–16. 10.1515/DMDI.2010.006. PMID 21417789.

P-гликопротеин.

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